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Other disease conditions in which melatonin may have utility as a treatment include cancer, cardiovascular disease, neurodegeneration, sepsis, drug toxicity, and many others

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SnCE1 is a true moonlighting enzyme, i.e., it has the primary catalytic activity acting as deSUMOylase, in which S1 and S1’ are bound by a SUMO2/3 chain, by a SUMO2/3-SUMO1 chain or by a non-SUMO substrate capped with SUMO1